She has appeared with many of the world's leading orchestras, including the New York Philharmonic, Boston Symphony Orchestra, Chicago Symphony Orchestra, Cleveland Orchestra, San Francisco Symphony, Los Angeles Philharmonic, Minnesota Orchestra, Pittsburgh Symphony Orchestra, The Met Orchestra (in Carnegie Hall), the Met Chamber Ensemble, Vienna Philharmonic, BBC Symphony Orchestra, Royal Philharmonic Orchestra, Philharmonia Orchestra, Orchestre de Paris, Bayerische Staatsoper Orchestra, Berliner Staatskapelle, Sao Paulo Symphony, and the Concertgebouworkest. She has also appeared in the prestigious festivals of Ravinia, Tanglewood, Aspen, Cincinnati, Saito Kinen, Edinburgh, Salzburg, and Lucerne.
The conductors with whom she has worked include Daniel Barenboim, Pierre Boulez, James Conlon, Sir Colin Davis, Stéphane Denève, Christoph von Dohnányi, Gustavo Dudamel, Christoph Eschenbach, Bernard Haitink, Manfred Honeck, James Levine, Lorin Maazel, Zubin Mehta, Kent Nagano, Seiji Ozawa, Antonio Pappano, Andre Previn, David Robertson, Donald Runnicles, Esa-Pekka Salonen, Mariss Jansons, and Michael Tilson Thomas.
Ms. DeYoung has also appeared with many of the finest opera houses of the world including the Metropolitan Opera, the Lyric Opera of Chicago, the Houston Grand Opera, the Seattle Opera, the Glimmerglass Opera, La Scala, the Bayreuth Festival, Berliner Staatsoper, the Opera National de Paris, the Thèâtre du Châtelet, and the Tokyo Opera. Her many roles include Fricka, Sieglinde and Waltraute in The Ring Cycle; Kundry in Parsifal, Venus in Tannhäuser, Brangäne in Tristan und Isolde, Dido in Les Troyens, Eboli in Don Carlos, Marguerite in La Damnation de Faust, Judith in Bluebeard's Castle, Gertrude in Hamlet, Jocaste in Oedipus Rex, and the title role in The Rape of Lucretia. She also created the role of the Shaman in Tan Dun's The First Emperor at the Metropolitan Opera.
In recital, Ms. DeYoung has been presented by the University of Chicago Presents series, the Ravinia Festival, Weill Recital Hall, Alice Tully Hall, San Francisco Symphony's Great Performances series, Cal Performances in Berkeley, SUNY Purchase, Calvin College, the Pittsburgh Symphony, Roy Thomson Hall, the Thèâtre du Châtelet, the Gulbenkian Foundation (Lisbon) the Edinburgh Festival, London's Wigmore Hall and Brussels's La Monnaie.
Ms. DeYoung's recording of Kindertotenlieder and Mahler's Symphony No. 3 with Michael Tilson Thomas and the San Francisco Symphony for SFS Media was awarded the 2003 Grammy Award for Best Classical Album. She has also been awarded the 2001 Grammy Awards for Best Classical Album and Best Opera Recording for Les Troyens with Sir Colin Davis and the London Symphony Orchestra. Her growing discography also includes a new recording of Mahler Symphony No 3 with the Chicago Symphony Orchestra and Bernard Haitink; Bernstein's Symphony No. 1, "Jeremiah"; with the BBC Symphony Orchestra and Leonard Slatkin for Chandos, Das Klagende Lied with the San Francisco Symphony and Michael Tilson Thomas for BMG,and Das Lied von der Erde with the Minnesota Orchestra for Reference Recordings. Her first solo disc was released on the EMI label.
This season, Ms. DeYoung makes her debut at the Basel Opera as Amneris in Aida, sings Das Lied von der Erde with the Met Orchestra and Oedipus Rex with the Boston Symphony Orchestra, both conducted by James Levine, and appears in performances of Bluebeard's Castle with Esa-Pekka Salonnen and the New York Philharmonic.